Herein lie the "Lost" Boreas Files by Rockessence

Boreas
Member
Posts: 433
From: Namsos, Norway
Registered: Jan 2004
  posted 01-20-2005 21:44              
--------------------------------------------------------------------------------
News from The European Genome Project;
Disentangling the Effects of Demography and Selection in Human History

By
Jason E. Stajich and Matthew W. Hahn

Demographic events affect all genes in a genome, whereas natural selection has only local effects. Using publicly available data from 151 loci sequenced in both European-American and African-American populations, we attempt to distinguish the effects of demography and selection. To analyze large sets of population genetic data such as this one, we introduce "Perlymorphism," a Unix-based suite of analysis tools. Our analyses show that the demographic histories of human populations can account for a large proportion of effects on the level and frequency of variation across the genome. The African-American population shows both a higher level of nucleotide diversity and more negative values of Tajima's D statistic than does a European-American population. Using coalescent simulations, we show that the significantly negative values of the D statistic in African-Americans and the positive values in European-Americans are well explained by relatively simple models of population admixture and bottleneck, respectively. Working within these nonequilibrium frameworks, we are still able to show deviations from neutral expectations at a number of loci, including ABO and TRPV6. In addition, we show that the frequency spectrum of mutations—corrected for levels of polymorphism—is correlated with recombination rate only in European-Americans. These results are consistent with repeated selective sweeps in non-African populations, in agreement with recent reports using microsatellite data
http://www.nature.com/cgi-taf/DynaPage.taf?file=/ejhg/journal/v13/n2/abs/5201321a.html&dynoptions=doi1106273964

--------------------
More repports on the HG;
http://www.nature.com/ejhg/journal/v13/n2/index.html
-------------------- http://www.nature.com/cgi-taf/DynaPage.taf?file=/ejhg/journal/v13/n2/full/5201330a.html#bib3
-------------------- http://www.genetics.org/cgi/content/abstract/167/2/867?view=abstract http://www.nature.com/cgi-taf/DynaPage.taf?file=/ejhg/journal/v13/n2/full/5201329a.html
---------------------
Not to forget the last on the “diversion of the species” – leading up to the origin of the human genome; http://www.nature.com/cgi-taf/Dynapage.taf?file=/nature/journal/v433/n7023/abs/nature03211_fs.html