America's 1st Serial Killer

While in Chicago, Holmes came across Dr. E.S. Holton's drugstore. It was located at the corner of Wallace and Sixty-Third in the suburb of Englewood. Holton was suffering from cancer while his wife minded the store. Through his charm, Holmes got a job there and then manipulated her into letting him purchase the store. The agreement was that she could still live in the upstairs apartment even after Holton died. Once Holton died, Holmes murdered Mrs. Holton and told people she was visiting relatives in California. As people started asking more and more when she would be coming back, he elaborated the lie and told them she loved it so much in California that she decided to live there. He then purchased a lot across from the drugstore, where he built his three-story, block-long Castle.

Holmes opened it as a hotel for the World's Columbian Exposition in 1893, using the rest of the structure for shops he rented. The bottom floor of the Castle contained these shops (one a jeweler, for example), while the upper two floors contained his personal office as well as a maze of over one hundred windowless rooms with doorways that would open to brick walls, oddly angled hallways, stairways to nowhere, doors that could only be opened from the outside, and a host of other strange and labyrinthine constructions.

Over a period of three years, Holmes selected female victims from among his employees, lovers, and hotel's guests, and tortured and killed them. Some were locked in soundproof bedrooms fitted with gas lines that permitted him to asphyxiate them at any time. Some victims were locked in a huge bank vault near his office; he sat and listened as they screamed, panicked and eventually suffocated. Holmes had repeatedly changed builders during the initial construction of the Castle to ensure that only he fully understood the design of the house he had created, thereby decreasing the chances of any of them reporting it to the police. In addition, according to law at that time, by firing workers every two weeks, he didn't have to pay them. The victims' bodies went by a secret chute to the basement, where some were meticulously dissected, stripped of flesh, crafted into skeleton models, and then sold to medical schools. Holmes also cremated some of the bodies or placed them in lime pits for destruction. Holmes had two giant furnaces as well as pits of acid, bottles of various poisons, and even a stretching rack to create a race of "giants". Because of the connections he gained through medical school, he was able to sell skeletons and organs with little difficulty.